National Projects

Protaminization of somatic cells nuclei as a model for nuclear reprogramming in somatic cell nuclear transfer.

Head of the project: dr hab. Marta Czernik

Period of realization: 2020-2023

Epigenetic effect on therapeutic activities of all-trans-retinoic acid in acute myeloid leukemia

Head of the project: dr Artur Zelent

Period of realization: 2020-2023

Molecular mechanisms of transplacental iron transport and regulation of iron metabolism in domestic pig and wild boar neonates: comparative studies

Head of the project: dr hab. Paweł Lipiński

Period of realization: 2020-2023

Mechanisms of trophectoderm differentiation in rabbit embryos

Head of the project: dr hab. Anna Piliszek

Period of realization: 2018-2023

Obtaining and identifying the pluripotency features of induced pluripotent cells of the European bison Bison bonasus bonasus 

Head of the project: dr Agnieszka Bernat-Wójtowska

Period of realization: 2018-2021

Effect of long-term action of corticosterone on brain transcripts of laboratory mice

Head of the project: dr Grzegorz Juszczak

Period of realization: 2018-2021

Study of the Effect of Transcriptional Network Disruption on Liver Cancer Development: Functional Analysis of HNF4A Mutation Using the CRISPR / Cas9 System

Head of the project: dr Hiroaki Taniguchi

Period of realization: 2018-2021

Oral piglet supplementation with iron nanoparticles and lysosomal iron as an innovative therapy in the treatment of neonatal iron deficiency anemia: an understanding of the molecular mechanisms of iron absorption

Head of the project: dr hab. Rafał Starzyński

Period of realization: 2018-2021

The role of copper in the regulation of cellular mechanisms of iron export in pro-inflammatory macrophages

Head of the project: Aneta Jończy

Period of realization: 2018-2021

Epigenetic role of Prdm3 protein in neurogenesis

Head of the project: Paweł Leszczyński

Period of realization: 2018-2021

Functional study of the influence of rare BRAF gene mutations on the development of liver cancer using the CRISPR / Cas9 system

Head of the project: Magdalena Śmiech

Period of realization: 2018-2021

Investigation of genetic predisposition to rare neurodevelopmental diseases: Integration of genome, transcriptome and methylome analyzes with modeling using genome engineering techniques of induced human pluripotent stem cells differentiated into functional neurons

Head of the project: dr hab. inż. Paweł Lisowski

Period of realization: 2017-2020

Characterization of the epithelial-mesenchymal transformation (EMT) in the peri-implantation mouse embryo

Head of the project:Katarzyna Teresa Filimonow

Period of realization: 2018-2019

The potential role of the ubiquitin-proteasome system in the corpus luteum of cattle

Head of the project:dr Hiroaki Taniguchi

Period of realization: 2017-2018

Effect of genetically induced intrauterine growth inhibition (IUGR) on transcriptome and epigenome of fetal bovine animals

Head of the project: Karolina Rutkowska

Period of realization: 2017-2019

Disturbed expression of mitochondrial proteins affects the development of cloned embryos: a preventive strategy

Head of the project: Marta Czernik

Period of realization: 2017-2020

Influence of small ruminant virus (SRLV) infection on the pattern of immune system gene methylation and micron profile in milk somatic cells and blood leukocytes of dairy goats

Head of the project: Daria Reczyńska

Period of realization: 2017-2020

Blastomeres biopsy and the formation of the Metabolic Syndrome: an attempt to estimate risk in a mouse model

Head of the project: dr Federica Zacchini

Period of realization 2016-2019

Epigenetic regulations in mammary gland tissues of cows infected with coagulase-negative and coagulase-positive staphylococci

Head of the project:  prof. Emilia Bagnicka (konsorcjum z IZ PIB Balice)

Period of realization 2016-2020

Effect of omega-6 and omega-3 fatty acids on telomere length and shelterin protein levels in a mouse model

Head of the project: mgr  Magdalena Ogłuszka

Period of realization 2016-2019

Impact of omega-3 and omega-6 fatty acids contained in plant oil on telomere biology in porcine muscle tissue in-vivo studies and rat muscle cell in-vitro studies

Head of the project: mgr  Magdalena Ogłuszka

Period of realization 2016-2019

Influence of maternal and genetic factors on offspring behavior and placental transcripts in murine models of autism

Head of the project: dr Silvestre Sampino

Period of realization: 2015-2019

Polymorphisms of the regions coding 3'UTR candidate genes for cattle production traits and mechanisms regulating their expression by miRNAs.

Head of the project: prof. Lech Zwierzchowski

Period of realization: 2015-2018

Strategy for ensuring and evaluating the base of cheap, effective and safe fodder energy raw materials for animal production based on domestic resources, with particular emphasis on modern rye varieties. Member of the consortium.

Head of the project: dr hab. Jolanta Oprządek

Period of realization 2015-2018

Immunological response in the course of natural infection with small ruminant lentiviruses.
Head of the Project: Jarosław Kaba PhD, DSc/Professor Emilia Bagnicka PhD, DSc
Period of realization: 2014-2017

The placental transcriptome and epigenome in the intrauterine restricted growth feotuses in cattle.
Head of the Project: Krzysztof Flisikowski PhD
Period of realization: 2014-2017

Proinflammatory cytokines expression in milk somatic cells and blood leukocytes of goats infected with small ruminant lentiviruses.
Head of the Project: Justyna Paulina Jarczak MSc
Period of realization: 2014-2017

Identyfication and characterization of endometrial proteins in pre- and peri-implantation period in pigs - evaluation of gene expression differences at proteomic level in relation to transcriptomic profile.
Head of the Project: Dorota Anna Pierzchała MSc

Assessment of genetic basis of fear-related aggression in police dogs using the SNP microarrays technology and behavioural methods.
Head of the Project: Marta Walczak PhD
Period of realization: 2013-2016

Analysis of candidate genes determining fat in meat-type chickens.
Head  of the Project: Rafał Parada PhD
Period of realization: 2013-2016

The role of selenium in the regulation of expression levels of genes encoding proteins involved in the metabolic pathway of selenium and redox homeostasis in sheep.
Head of the Project: Edyta Juszczuk-Kubiak PhD
Period of realization: 2013-2016

Identyfication of new differentally methylated regions (DMRs) in swine targeted genes using methylome analysis (MeDIP) and next generation sequencing (NGS) for improvement of somatic cell nuclear transfer (SCNT) efficiency.
Head of the Project: Maciej Grzybek MSc
Period of realization: 2013-2016

The application of the fruit industry waste products in lambs fattening to obtain meat fulfilling the criteria of functional food.
Head of the Project: Paulina Lipińska MSc
Period of realization: 2013-2015

Genetic and epigenetic regulation of the genes encoding glucose transporters and lactose synthase in the  mammary gland cells of the cow.
Head of the Project: Professor Lech Zwierzchowski PhD, DSc
Period of realization: 2013-2015

Regulation of the molecular mechanisms of heme absorption: studies on piglets with iron deficiency anemia supplemented with heme iron.
Head of the Project: Rafał Starzyński PhD
Period of realization: 2013-2017

Development of humanized neurodegenerative diseases models using TAL effector nucleases.
Head of the Project: Paweł Lisowski PhD
Period of realization: 2013-2014

Reprogramming of somatic cells in the environment of early mouse embryo, characteristics of reprogrammed cells and derivation of embryonic stem cells from somato-embryonic chimaeras.
Head of the Project: Krystyna Żyżyńska MSc
Period of realization: 2012-2013

Differentiation of first cell lineages in mammalian embryos (rabbit model).
Head of the Project: Anna Piliszek PhD
Period of realization: 2012-2016

Paternal genealogy of cattle breeds included in the National Rare Livestock Breeds Preservation Programme.
Head of the Project: Beata Prusak PhD
Period of realization: 2012-2015

Identification of epigenetic biomarkers of stress in mouseIdentification of epigenetic biomarkers of stress in mouse.
Head of the Project: Adrian Stankiewicz MSc
Period of realization: 2012-2014

Development of alternative and effecive  strategies for induction full  nuclear reprogramming of  somatic nuclei introduced into enucleated MII oocytes.
Head of the Project: Magdalena Kotlarska MSc
Period of realization: 2011-2014

Pathogen - host interactions and  their genetic basis in chronic mastitis caused by staphylococc.
Head of the Project: Adrianna Pawlik MSc
Period of realization: 2011-2014

Transcriptomic profile of bovine skeleton muscle in the context of nutritional and health value of beef.
Head of the Project: Dagmara Robakowska-Hyżorek PhD
Period of realization:  2011-2014

The possibilities of feed intake capacity and growth rate in improvement of production and functional traits of dairy cattle with utilization of DNA microarray technology.
Head of the Project: Jolanta Małgorzata Oprządek PhD, DSc
Period of realization: 2011-2014

Changes in fatty acids metabolic pathways during growth of Japanese quails (Coturnix coturnix japonica).
Head of the Project: Ewa Poławska PhD, DSc
Period of realization: 2011-2014

Analysis of the genetic background of horse osteochondrosis.
Head of the Project: Dorota Lewczuk PhD, DSc
Period of realization: 2011-2014

Down-regulation of the Iron Regulatory Protein 1 expression in oxidative stress: molecular mechanisms, impact on intracellular iron metabolism, importance in the pathogenesis of Amyotrophic Lateral Sclerosis
Head of the Project: Paweł Lipiński PhD, DSc
Period of realization: 2011-2014

Derivation of genuine rabbit embryonic stem cells.
Head of the Project: Catalina Diaz MSc
Period of realization: 2011-2014