Researchers from The Institute of Genetics and Animal Biotechnology, of the Polish Academy of Sciences, the Max Delbrück Center for Molecular Medicine (MDC), the Berlin Institute for Medical Systems Biology (BIMSB), the Charité – Universitätsmedizin Berlin and the Heinrich Heine University Düsseldorf, using advanced technologies of human brain organoids and genome engineering, have identified an early, neurodevelopmental mechanism that affects the development of Huntington's disease through mitochondria.